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Keep track of Carefully (2)diazepam will boost the amount or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism.apalutamide will lessen the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medi